Characterization of inter- and intrafamilial variability in autosomal dominant polycystic kidney disease

Henry Gaspard Published in the journal : November 2018 Category : Mémoires de Recherche Clinique

Autosomal dominant polycystic disease (ADPKD) is the most common inherited renal disease, accounting for 5 to 10% of patients requiring renal replacement therapy. ADPKD is characterized by the development of multiple cysts in both kidneys, leading to end-stage renal disease (ESRD) before the age of 60 years in approximately half of patients. This multisystem disorder can potentially affect the liver, pancreas, heart, and intracerebral arteries. ADPKD is a genetically heterogeneous disease caused by mutations in the PKD1 and PKD2 genes.

Read more

Endoscopic management of postoperative pancreatic fistula

Gabriela Gujda, Catherine Hubert, Tom Moreels, Julie Navez, Enrique Perez Cuadrado-Robles, Pierre-Henri Deprez Published in the journal : November 2018 Category : Mémoires de Recherche Clinique

Postoperative pancreatic fistula (POPF) is one of the most prevalent clinically relevant complications following partial pancreatic resection. Endoscopic approaches have proven successful, but the literature regarding the best route of drainage is scarce. Our study was aimed at comparing the efficacy and safety of transpapillary (endoscopic retrograde cholangiopancreatography [ERCP]-based) and transmural (endoscopic ultrasound [EUS]-guided) endoscopic treatment of POPF occurring after distal pancreatectomy.

Read more

Liver regeneration and the role of hepatic progenitor cells in alcoholic steatohepatitis

Adrienne Lejeune(1,2), Peter Stärkel(1,2), Alexandre Louvet(3), Axel Hittelet(4), Céline Bazille(5), Boris Bastens(6), Hans Orlent(7), Luc Lasser(8), Xavier Dekoninck(9), Sergio Negrin Dastis(10), Jean Delwaide(11), Anja Geerts(12), et al. Published in the journal : November 2018 Category : Mémoires de Recherche Clinique

The role of liver progenitor cells (LPCs), which are known as severity markers in chronic liver diseases, remains poorly understood, as is the impact of macrophages on liver regeneration. We aimed to characterize these cell populations in severe alcoholic steatohepatitis (ASH) and determine whether their activation could be considered as a good prognostic factor.

Read more

Evaluation of the screening strategy for gestational diabetes at the Saint-Luc University Clinics “Maternal and fetal complications”: a retrospective analysis of 1,018 patients

Jeanne Cuvelier Published in the journal : November 2018 Category : Mémoires de Recherche Clinique

Gestational diabetes is a much debated condition in the medical world, and many studies carried out recently yielded divergent results as to the utility of the new screening criteria issued by the International Association of Diabetes and Pregnancy Study Group (IADSPG). The prevalence of diabetes has significantly increased over the past few years. This study’s aim was to clarify whether treating patients with "mild" gestational diabetes is beneficial.

Read more

Overlap syndrome and primary sclerosing cholangitis in childhood and adolescence: response to antibiotics and related changes in gut microflora and bile acid profile

Pauline Sambon(1,2), Amandine Everard(3,4), Xavier Stephenne(1,2), Françoise Smets(1,2), Isabelle Scheers(1,2), Mina Komuta(5,6), Giulio G. Muccioli(7), Patrice D. Cani(3,4), Etienne Sokal(1,2) Published in the journal : November 2018 Category : Mémoires de Recherche Clinique

The concurrent occurrence of autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC) is referred to as AIH/PSC overlap syndrome or autoimmune sclerosing cholangitis (ASC) in children. Though not evidence-based, it is standard practice to treat the AIH component with corticosteroids (CS) and azathioprine, and the PSC component with ursodeoxycholic acid (UDCA). Antibiotics (AB) are increasingly being reported to have favorable effects in PSC, but their role in ASC is poorly evaluated. We retrospectively investigated the response to oral ABs as initial or rescue therapy in ASC children. A historical control group included ASC patients receiving the recommended treatment. We prospectively analyzed the gut microbiota and serum bile acid (BA) profile before and after AB therapy in children with either ASC or PSC alone, and evaluated whether changes in gut microbiota and/or BAs correlated with the therapeutic response. 

Read more

How to track and register gastrointestinal endoscopy-related adverse events?

Francesca Chiara Della Casa Published in the journal : November 2018 Category : Mémoires de Recherche Clinique

Gastrointestinal endoscopic procedures have evolved significantly in the last 50 years, thereby revolutionizing the diagnosis and treatment of gastroenterological diseases. Although using the body’s natural openings to access the region of interest skillfully bypasses disruption of superficial tissues or muscular planes, endoscopy remains an invasive technical procedure, which is thus associated with risks and complications. As a part of every quality program in medicine, tracking adverse events represents a quality indicator, which has been widely accepted as a monitoring measure. This study’s aim was to elaborate a practical system for reporting the endoscopic procedure-associated adverse events occurring in the department of gastroenterology of the Saint-Luc University Hospital.

Read more

Prevalence of pituitary insufficiency in patients with nonfunctioning pituitary macroadenoma and evolution following neurosurgical treatment: a study of 150 patients

Valérie Everard Published in the journal : November 2018 Category : Mémoires de Recherche Clinique

Non-functioning pituitary macroadenomas (NFPA) are supracentimetric adenomas whose main symptoms (visual impairment, pituitary insufficiency, headaches) are caused by the compression of adjacent anatomical structures. NFPA are mostly treated by transsphenoidal tumor resection in order to correct or avoid symptoms caused by mass effects. Limited data are available regarding the evolution of pituitary functions following surgery.

Read more

Predictors of response to new immunomodulatory therapies in melanoma

Alexia Degraeuwe(1) Published in the journal : November 2018 Category : Mémoires de Recherche Clinique

Immune checkpoint inhibitors have revolutionized the treatment of metastatic melanoma, with a survival now reaching several years in some patients. The anti-PD-1 monoclonal antibodies nivolumab and pembrolizumab increase both the quality of life and overall survival of metastatic melanoma patients. They are currently the first-line treatment for metastatic melanoma. However, only 40% of patients respond to anti- PD-1 monotherapy. In the era of personalized medicine, it has become essential to identify those patients who will benefit from these treatments that are, by the way, responsible for rare but serious adverse events. We tested several immunohistochemical markers in order to discriminate between responders and nonresponders.

Read more

Study of compliance with follow-up in melanoma patients

Laura Baumel, Aline Van Maanen, David Ogez, Isabelle Tromme Published in the journal : November 2018 Category : Mémoires de Recherche Clinique

Melanoma is associated with a high risk of recurrence and new primaries. A lifelong follow-up is thus recommended. This study was aimed at identifying the factors that could influence the patient’s compliance with dermatological and oncological follow-up.

Read more

Allergic contact dermatitis to synthetic rubber gloves in caregivers

Guillaume Dejonckheere Published in the journal : November 2018 Category : Mémoires de Recherche Clinique

A growing number of hospitals decided to completely abandon latex in order to avoid IgE-mediated allergic reactions (which can lead to anaphylaxis), as was the case for the Saint-Luc University Clinics in December 2010 (a premiere in Belgium). This measure concerns more than 300,000 pairs of sterile gloves per year. Since then, many caregivers who had been working for years without experiencing any allergic reaction developed contact dermatitis with the new gloves. The main allergens involved are vulcanization accelerators.

Read more