XULTOPHY®, A COMBINATION OF BASAL INSULIN AND LIRAGLUTIDE: ROLE IN THE TREATMENT OF TYPE 2 DIABETES

Martin Buysschaert Published in the journal : September 2018 Category : Diabétologie

Xultophy® is a new combination product consisting of basal insulin (degludec) and a GLP-1 agonist (liraglutide). In this article, we analyzed recent literature in order to find out its potential advantages in general and compared to basal insulin in particular, as well as to clarify its role in the therapeutic management of insulinrequiring type 2 diabetes. 

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Comparison of tacrolimus plus induction via intraoperative single high-dose of rabbit anti-T-lymphocyte globulins versus tacrolimus monotherapy in adult liver transplantation: 1-year results of an investigator-driven randomized controlled trial

Kevin Ackenine(1), Samuele Iesari1, (2), Maxime Foguenne(1), Chantal De Reyck(1), Eliano Bonaccorsi Riani(1), Olga Ciccarelli(1), Laurent Coubeau(1), Quirino Lai(3), Mina Komuta(4), Pierre Gianello(5), Jan Lerut(1) Published in the journal : July 2018 Category : Mémoires de Recherche Clinique

The efficacy of anti-lymphocyte serum (ALS) induction remains inconclusive in liver transplantation (LT) due to poorly designed trials.

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Acute liver failure in children: experience of a paediatric intensive care unit

Valentine Hermans(1), Thierry Detaille(1), Astrid Haenecour(1), Emilien Derycke(1), Laurent Houtekie(1), Raymond Reding(2), Stéphan Clément de Cléty(1) Published in the journal : July 2018 Category : Mémoires de Recherche Clinique

Pediatric acute liver failure (PALF) is a rare yet severe condition characterized by rapidly progressing hepatic dysfunction and multisystem organ failure (MOF) syndrome in previously healthy children. It poses several clinical challenges to physicians, one of them being the identification of the children who won’t recover without liver transplantation (LT).

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Prognostic factors of acute mesenteric ischemia in the intensive care unit

Martin Caluwaerts(1), Diego Castanares-Zapatero(1), Pierre-François Laterre(1), Philippe Hantson(1) Published in the journal : July 2018 Category : Mémoires de Recherche Clinique

Acute mesenteric ischemia (AMI) is a frequent cause of acute abdomen in the elderly, which is commonly encountered in the intensive care unit (ICU). AMI has a high mortality rate of between 60 and 80%, as well as a high morbidity rate among survivors. One of the reasons for this poor prognosis is the lack of accurate diagnostic tools for the clinician, with a delayed diagnosis as the main consequence. The characteristics of AMI diagnosed in the ICU often differ from those found in the general population, which results in a real diagnostic challenge. In the ICU, the interpretation of clinical, biological, and radiological signs of AMI proves more difficult. Furthermore, the poor prognosis is also accounted for by the numerous comorbidities of intensive care patients.

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Impact of intraoperative 3D fluoroscopy-based neuronavigation during percutaneous pedicle screw fixation in the degenerative lumbar spine

Julien Pierrard, Christian Raftopoulos, Edward Fomekong Published in the journal : July 2018 Category : Mémoires de Recherche Clinique

Given the aging population and increasing prevalence of degenerative diseases of the spine, neurosurgeons need to perform more lumbar fusions with pedicle screw fixations. As these interventions are currently carried out percutaneously, surgeons are dependent on intraoperative imaging to replace the anatomical landmarks found in open procedures. In our institution, we recently acquired a neuronavigation system based on intraoperative 3D fluoroscopy.

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Extracerebral vascular phenotype in autosomal dominant polycystic kidney disease

Thibault Wallez, Nathalie Demoulin, Yves Pirson Published in the journal : July 2018 Category : Mémoires de Recherche Clinique

Autosomal dominant polycystic kidney disease (ADPKD), caused by PKD1 or PKD2 mutations, is the most common inherited kidney disease. Intracranial aneurysms (ICA) and mitral valve prolapses are well-known vascular complications in ADPKD patients. Other reported vascular manifestations include thoracic aortic aneurysms and dissections (TAAD) and cardiomyopathies (CMP).

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Non-invasive assessment of fibrosis in alcoholic liver disease

Mélissa Salavrakos(1), Hubert Piessevaux(1), Mina Komuta(2), Nicolas Lanthier(3), Peter Stärkel(3) Published in the journal : July 2018 Category : Mémoires de Recherche Clinique

Transient elastography (TE), or Fibroscan®, has been validated for the diagnosis and staging of liver fibrosis in chronic hepatitis C, but there is no clear consensus on the optimal TE cut-off values in alcoholic liver disease (ALD). The objectives of the study were: (a) to evaluate the cut-off values reported in the literature and determine new ones for the diagnosis of fibrosis in alcoholic patients; (b) to investigate the impact of 2 weeks of abstinence on TE results; (c) to evaluate the diagnostic accuracy of TE for detecting clinically significant portal hypertension; (d) to evaluate the accuracy of non-invasive blood tests (AST-Platelet Ratio Index [APRI], Forns index, Fibrosis-4 [FIB-4]); (e) to study the potential histological (steatosis, alcoholic hepatitis, perisinusoidal fibrosis) and biochemical (transaminases and cholestasis) confounding factors leading to misclassification by TE.

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Prospective study evaluating the endocrine and exocrine function of the pancreas after endoscopic treatment of chronic pancreatitis

Shabneez Kautbally(1), Pierre Deprez(1), Michel Hermans(2), Tom Moreels(3), Tarik Aouattah(3), Enrique Perez-Cuadrado-Robles(3) Published in the journal : July 2018 Category : Mémoires de Recherche Clinique

Studies reporting on pancreatic function after endoscopic treatment of chronic pancreatitis are scarce. This study was aimed at prospectively investigating the evolution of pancreatic endocrine and exocrine function in patients who underwent endoscopic treatment using endocrine function parameters and fecal tests for exocrine function.

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Partial remission of type 1 diabetes in children: characterization of this period according to the IDAA1C definition and proposal of an alternative definition integrating routine parameters reflecting glycemic variability

Nina Nielens(1), Annie Robert(2), Philippe Lysy(1) Published in the journal : July 2018 Category : Mémoires de Recherche Clinique

In the first months following diagnosis, type 1 diabetes patients frequently experience a transient period of partial remission during which glycemic control can be achieved easily with reduced, or even suspended, insulin requirements. Over the past years, different criteria have been used in the literature to define this period, rendering it sometimes difficult to compare study results. In 2009, Mortensen et al. [1] proposed a new definition of the remission phase: the IDAA1C (Insulin Dose-Adjusted A1C = HbA1C + 4 x insulin doses/day/kg), with an IDAA1C ≤9 indicating that the patient is in remission phase. Though this formula is currently the most widely used in the literature, some authors criticize that it integrates the «insulin doses» parameter, as it may be influenced by several confounding factors.

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Unicompartmental versus total knee arthroplasty: assessment of quadriceps muscle and impact of tourniquet compression

Aurélie Vanden Berghe, Emmanuel Thienpont Published in the journal : July 2018 Category : Mémoires de Recherche Clinique

Knee arthroplasty has been constantly evolving since it was introduced in the late 1960’s as a new treatment option for knee osteoarthritis. Unicompartmental (UKA) and total knee arthroplasty (TKA) have the same treatment objectives, namely relieving symptoms and allowing patients to return as soon as possible to normal life so that they can engage in daily activities, as well as in recreational and social events. Interestingly, several studies demonstrated a better recovery in patients that underwent UKA compared to those who were subjected to TKA. Our study hypothesized that patients eligible for UKA initially have a stronger and more powerful quadriceps muscle and thus a better performing muscle than those eligible for TKA. These preoperative muscle properties may play a major role in the improved recovery process observed in patients operated by UKA.

Key words
Knee, arthroplasty, quadriceps, limb preconditioning.

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