Two clinical aspects are discussed this year for the Child and Adolescent Psychiatry Service of the Cliniques universitaires Saint-Luc. They describe the help and care offers implemented to cope with the increase of mental distress situations of children, adolescents, and their families. The first part concerns the deployment of the reference center for Autism Spectrum Disorder, namely the establishment of an early stimulation group for young children awaiting diagnosis and a “parent training” group after diagnosis. The second part encompasses the consolidation of legal time within the SOS-Children team of the Clinics; where we will show the merits and contributions of this specific function in complex cases of child abuse.

During 2022, the ENT department focused on the well-being of the patients in all sub-disciplines of our specialty. First, we were pleased to obtain reimbursement of long-awaited biological products for the treatment of patients with chronic rhinosinusitis with nasal polyps. These new therapies are able to help a significant number of patients whose disease cannot be controlled by standard medical and surgical treatments. Second, we were able to review a series of more than 250 patients who underwent parotidectomy with intraoperative neuromonitoring. We found that preservation of facial nerve function was significantly better compared with previously reported data on parotidectomies without neuromonitoring. Finally, in the field of cochlear implantation for patients with severe hearing loss, we are currently preparing for the future. New techniques have been developed in order to maintain residual hearing during the implant’s insertion into the cochlea, such as robotic surgery and intraoperative electrocochleography. These techniques will allow us to increase the indications for implantation, which will lead to more patients being able to benefit from this life-changing technology.

We discuss the negative results of a randomized controlled trial of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers cessation in G4 or G5 stage chronic kidney disease. We next review the initiation modalities of dapagliflozine and finerenone in chronic kidney disease patients. Lastly, we review the recent therapeutic advances in IgA nephropathy treatment.

The specific characteristics of the CD19 cell marker make it an ideal therapeutic target in the treatment of B-cell lymphoma. Several molecules targeting CD19 have recently been made available, or are currently being developed, and show promising results for this therapeutic indication. This seems to be particularly true in the management of relapsing or refractory diffuse large B-cell lymphoma, as demonstrated by the results of the different studies described in this article. The choice of the right molecule and the best sequence for these treatments is still to be defined.