Prevention of venous thromboembolism in medical patients: What role for fondaparinux (Arixtra®)?

Cédric Hermans Published in the journal : December 2023 Category : Actualité thérapeutique

Venous thrombotic events (deep vein thrombosis and pulmonary embolism) represent a major complication among hospitalized patients. For a long time, venous thromboembolism (VTE) was the focus of attention during surgical procedures. Today, however, it is among patients admitted for acute or chronic medical conditions that VTE is increasingly raising concerns and interest.

The incidence of VTE in medical patients, its lack of consideration, and insufficient prevention cannot be ignored. Systematic and rigorous assessment of the thrombotic risk in all admitted medical patients and consequent monitoring during their stay is a priority.

While low-molecular-weight heparins (LMWHs) have established themselves as the reference preventive antithrombotic agents, including in medical patients, the pentasaccharide fondaparinux (Arixtra®) represents an attractive alternative.

The properties of this synthetic molecule and its validation in clinical studies should make this anticoagulant a preferred alternative or a first-line agent for VTE prevention in medical patients.

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Innovations in vaccinology

Julien De Greef Published in the journal : December 2023 Category : Maladies infectieuses

Several new vaccines have recently been developed, some of which are now available on the Belgian market. This article presents an overview of new vaccines against pneumococcus, respiratory syncitial virus, influenza, shingles and dengue fever.

Vaccine advances against malaria are also discussed.

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Voluntary massive elemental mercury poisoning

Caroline Vincent (1), Thalia de Ruffi (1), Wolfgang Schuller (2), Denis Hers (3), Anne Toussaint (3) Published in the journal : December 2023 Category : Psychiatrie

We hereby report on the case of a 40-year-old patient who used elemental mercury for suicidal purposes by voluntary ingestion of approximately 100 mL. We describe this unusual form of suicide attempt and present the different short- and long-term consequences. We emphasize the need for caretakers to anticipate the collection of disposed mercury, in order to avoid environmental polluting and associated consequences. We also mention the importance of collaboration between somatic physicians and psychiatrists to limit institutional consequences.

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From the trivialization of trauma to its invisibilization, how to prevent post-traumatic stress disorder?

Claire Mairiaux (1), Sylvain Dal (2) Published in the journal : December 2023 Category : Psychiatrie

Despite the popularization of the mechanisms of psychological trauma and vulgarization of related concepts, this article suggests a form of invisibilization of post-traumatic pathologies and the secondary insufficiency of their management. This article presents different explanations for this invisibilization, as well as concrete avenues for treatment.

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Nitrous oxide intake and neurotoxicity

Bastien Tossens (1)*, Romane Ponthot (1)*, Sofia Maldonado Slootjes (2), Damien Gruson (1), Vincent Haufroid (1), Joseph P. Dewulf (1), Kevin-Alexandre Delongie (1), Guillaume Grzych (3), Lidvine Boland (1) Published in the journal : December 2023 Category : Biochimie médicale

Nitrous oxide (N2O) is an anesthetic gas, also consumed for its euphoric properties, which can cause serious health problems. In this report, we present the case of a 23-year-old man who has been regularly consuming this gas since 2018, with a progressive intensification of his consumption, leading to subacute myeloneuropathy. Given a similar context, a previous diagnosis of Guillain-Barré syndrome in 2021 is questioned. We review the laboratory tests to be performed in the management of a patient presenting motor and sensory neuropathies associated with N2O consumption, namely homocysteine and methylmalonic acid (MMA) assays.

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Expectations of general practitioners and pharmacists regarding health data communication: a cross-sectional survey in the Wallonia-Brussels Federation

Florent Guyaux (1), Annick Nonneman (2) Published in the journal : December 2023 Category : Médecine Générale

Objective

This study aims to explore the expectations of pharmacists and general practitioners (GPs) regarding the exchange of medi­cal data via health networks.

Methodology

A quantitative questionnaire study was conducted among pharmacists and general practitioners in the Wallonia-Brussels Federation (FWB). Data were analyzed using descriptive statistics.

Results

The questionnaire yielded a sample of 609 people. Overall, 83% of GPs wanted access to the medication dispensing history, 93% of pharmacists wanted to access the full Summarized Electronic Health Record (SUMEHR), and 62% of GPs favored sharing this SUMEHR with the pharmacists believing it would improve their collaboration and treatment control. However, less than 10% of GPs agreed with sharing more sensitive data such as medical reports or biological results, while 64% of doctors believed the indication for treatment should be shared with pharmacists on an optional basis. More than 70% of GPs and pharmacists preferred to use specific communication tools between themselves.

Conclusion

GPs and pharmacists are looking for health networks to facilitate communication, health data exchange, and access to medication history and patterns. Their underuse can be partially explained by insufficient knowledge of the tools, difficulty of access, bugs, respect for privacy, non-implementation of the tools in business software, time-consuming encoding and fear of judgment of drug prescriptions, or the transfer of the GP’s role to the pharmacist.

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Pediatric palliative care: for whom? Current situation in Belgium

Manon Le Roux (1,2), Dominique Bellis (3), Brigitte de Terwangne (3), Bénédicte Brichard (1,2) Published in the journal : October 2023 Category : Pediatric Hematology/ Oncology

Palliative care is intended for children with life-limiting or life-threatening illnesses, regardless of age and pathology, and their families.

It is not limited to children at the end of life. Palliative care begins as soon as an illness is diagnosed and includes, in varying proportions over time, treatments that are still directed against the illness, as well as comfort care.

Palliative care requires an interdisciplinary approach and is tailored to the physical, psychological, social, and spiritual needs of children and their families, with the aim of improving their quality of life. Palliative care continues after the child’s death by supporting the family.

Many children are concerned by palliative care, but only a minority will benefit from structured care. In Belgium, there are pediatric liaison teams whose role is to provide palliative care for children and adolescents in hospitals and at home.

There is a real need for communication and information regarding this subject, and to broaden the range of training courses available.

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Vasculitis: from clinical and pathological descriptions to successful treatments

Loïc Guillevin Published in the journal : October 2023 Category : Docteur Honoris Causa

Systemic vasculitis is a group of inflammatory diseases of vessels of various sizes, with variable pathogenic mechanisms. Their causes are often unknown. This disease group is historically dominated by polyarteritis nodosa but also includes granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, and giant cell arteritis. Immunologically, anti-neutrophil cytoplasmic antibodies (ANCA) are present in a group of small-sized vessel necrotizing vasculitis. The extremely severe prognosis of vasculitis has been modified by corticosteroids and immunosuppressive treatments. More recently, biotherapies, including rituximab in ANCA-associated vasculitis, mepolizumab in eosinophilic granulomatosis with polyangiitis, and tocilizumab in giant cell arteritis, have achieved remissions in more than 90% of patients and prevented relapses. They have also made possible to considerably reduce corticosteroid treatment and, consequently, its side effects. Vasculitis is now curable with a favorable prognosis.

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New recommendations for the management of acute otitis media in primary care

Jan-Harm Keijzer (1), Saphia Mokrane (1,2), Paul Van Royen (3), Nicole Dekker (1), Martine Goossens (1), Olivier Vanderveken (4), An De Sutter (5), Rupal Mehta (6), Cécile Ducène (7), Alexandra Sousa (8), Monique Boulad (9) Published in the journal : October 2023 Category : Médecine Générale

This article is a summary of the recent update of the clinical practice guideline (CPG) on the management of acute otitis media (AOM) in general practice.

The CPG was developed with the participation of all relevant disciplines and according to an internationally recognized methodology for guideline development (Adapte procedure).

The elements of the medical history and clinical examination have limited diagnostic value and symptoms alone are not enough to make a diagnosis of AOM. The diagnostic hypothesis is based on the combination of these elements.

The doctor pays attention to the patient's experience and provides the necessary information to enable the patient to manage his/her disease properly (e.g., pain management, etc.). Shared decision making is a key point.

Antibiotics are justified in case of an unfavorable disease course and in the presence of major risk factors for complications. However, certain subgroups may benefit from antibiotic treatment.

Effective treatment (paracetamol or ibuprofen) of pain or fever has become the cornerstone of AOM management. More targeted antibiotic treatment is reserved for specific indications.

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High-flow priapism after pelvic fracture

Romain Carlat (1), Renaud Destraix (4), Nicolas Jacquemart (2), François Melebeck (3), Michaël Twahirwa (4), Michaël De Foy (3) Published in the journal : October 2023 Category : Chirurgie orthopédique

Priapism is an erectile dysfunction characterized by partial or complete penile erection lasting more than four hours without any sexual stimulation. Its incidence is estimated at 0.5-0.9 cases per 100,000 people per year. Ischemic priapism, which is more frequent and painful, is induced by the paralysis of the cavernous smooth muscle, which can no longer contract, allowing hypoxic blood to stagnate within the sinusoidal spaces. Arterial priapism, rare (5% of priapism) and typically painless, generally results from direct perineal trauma responsible for an arterio-cavernous fistula. In this case report, we discuss the multidisciplinary management of a 31-year-old patient, polytraumatized after a high-velocity motorcycle accident. He presented with a pelvic fracture osteosynthesized with a plate and screws. Following surgery, the patient developed post-traumatic high-flow priapism, which was managed by interventional radiology.

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