NK cell phenotype as a risk marker of post-transplant lymphoproliferative disease in liver-transplanted children

Ugo Bréda, Xavier Stephenne, Pascale Saussoy, Etienne Sokal, Françoise Smets Published in the journal : June 2016 Category : Mémoires de Recherche Clinique

Post-transplantation lymphoproliferative disease (PTLD) is a serious complication in liver-transplanted children, most often related to Epstein-Barr virus (EBV) infection...

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Esophageal variceal bleeding risk assessment in children with decompensated cirrhosis waitlisted for liver transplantation

Nicolas Bonnet, Françoise Smets, Françis Veyckemans, Thibault Helleputte, Stéphane Eeckhoudt, Cédric Hermans, Etienne Sokal, Xavier Stephenne Published in the journal : June 2016 Category : Mémoires de Recherche Clinique

Cirrhotic children who are waitlisted for liver transplantation are prone to bleeding from ruptured esophageal varices, with Grade 2-3 varices and red signs as known risk factors...

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Dermatology and endocrinology

C. Colmant, D. Maiter, B.Vandeleene, M. Baeck, L. de Montjoye Published in the journal : September 2015 Category : Dermatology

We here report on the “PEAU’se dermatologique” meeting that took place on October 22, 2015, dedicated to dermatological and endocrine diseases. Professor D. Maiter gave us the clues to optimal corticosteroid use in dermatological practice, from treatment initiation to withdrawal. Next, Professor B. Vandeleene reminded us of the cornerstones of diabetic foot management. Finally, Professor M. Baeck presented several clinical cases of dermatological diseases in the diabetic patient.

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Clinical work-up for cognitive disorders and falls leading to the diagnosis of CADASIL-type cerebral angiopathy

E. Levecque, N. Cals Published in the journal : September 2015 Category : Neurology

CADASIL disease is a rare autosomal dominant hereditary angiopathy, primarily characterized by significant white matter damage on MRI. We have herein described a case of Cadasil disease discovered somewhat fortuitously, owing to its insidious symptom onset and the causal mutation 's strongly suspected transmission to the patient’s son.

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THE ERA OF NEW ORAL ANTICOAGULANTS

M. Einhorn Published in the journal : June 2016 Category : Hematology/Oncology

On February 16th, a round table was held in Brussels dealing with new oral anticoagulants. On this occasion, Belgian experts exchanged views with Professor Giancarlo Agnelli.

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Precocious puberty

V. Beauloye Published in the journal : May 2016 Category : Endocrinology

Precocious puberty (PP) is a most common condition encountered in pediatric endocrinology practice. Articles reporting on increasingly early pubertal development have recently been published in the lay press, thus resulting in numerous questions from parents regarding their children's pubertal development. PP can be defined as the onset of secondary sexual characteristics, along with accelerated growth and bone maturation, occurring earlier than usual, e.g., prior to the age of 8 years in girls and 9 in boys. PP etiologies can be divided into gonadotropinreleasing hormone (GnRH)-dependent and GnRH-independent causes. GnRHdependent PP, often referred to as central PP, is usually treated using GnRHagonists.

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DIRECT ORAL ANTICOAGULANTS (DOACs)

Ph. Hainaut Published in the journal : May 2016 Category : Thérapeutique

Direct oral anticoagulants (DoaCs) offer significant benefits for the treatment of nonvalvular atrial fibrillation and venous thromboembolism. these agents are simpler to use than others, as they do not require routine laboratory monitoring and dose adjustment. moreover, DoaCs have been shown to reduce severe bleedings, and especially intracranial bleedings, as compared to vitamin k antagonists. real-life clinical data confirmed these benefits that had previously been shown in randomized clinical trials.

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Dyslipidemia: What's new in 2016?

O.S. Descamps Published in the journal : May 2016 Category : Thérapeutique

This article describes several advances made in the dyslipidemia and cardiovascular prevention fields. These novelties pertain to the three steps of prevention: prediction including screening for two common, but often ignored, genetic abnormalities, namely familial hypercholesterolemia and elevated lipoprotein(a) levels, planning with the emergence in recommendations of a new target called "non-HDL cholesterol or non-HDL-C" in addition to the conventional "LDL-cholesterol or LDL-C" target, and prescription with the possible option of combining statins with other therapeutic classes.

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Optimal use of immunosuppressive drugs

F.A. Houssiau Published in the journal : May 2016 Category : Thérapeutique

The mechanism of action of the most commonly prescribed immunosuppressive drugs, as well as their dosage and adverse effects, are highligted in this article, with particular emphasis on toxicity prevention and treatment monitoring by general practitioners.

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Clinical evaluation in pediatric orthopedic practice: What should the general practitioner know?

M Mousny, A Renders Published in the journal : May 2016 Category : Pediatrics

Nowadays, pediatric orthopedics is considered a fully-fledged specialty, which differs from adult orthopedics in terms of both the pathologies encountered and the clinical approach. This article describes the “general” orthopedic clinical evaluation as performed by the authors in their daily practice. A particular emphasis is placed on the clinical aspects that may help general practitioners distinguish the normal from the pathological. Of note is that this article only addresses clinical assessment of walking-age children, in a timely fashion that is believed to progressively favor patient compliance.

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