LDL-cholesterol is the major therapeutic target in the management of cardiovascular risk factors. Several dietary interventions showed significant improvements whilst lowering blood LDL-C levels, such as replacing atherogenic fats by unsaturated fats, eating plant sterols from enriched foods, increasing soluble fiber consumption, consuming unsalted nuts, and, at times reducing dietary cholesterol. When considered separately, each result seems modest. If we however associate the proposed dietary interventions, the results are cumulative, resulting in a greater impact on LDL-C levels that decrease by 20 to 30%. This is relevant for primary prevention and for target groups at the highest cardiovascular risk, thereby increasing the nutritional quality of the diet.