Neurological implications of SARS-CoV-2 infection

Pietro Maggi, Antoine Guilmot, Sofia Maldonado Slootjes, Caroline Huart, Bernard Hanseeuw, Thierry Duprez, Julien De Greef, Leila Belkhir, Jean Cyr Yombi, Adrian Ivanoiu, Vincent van Pesch Published in the journal : May 2020 Category : Neurology

Summary :

A steadily increasing number of cases with neurological manifestations that are potentially related to COVID-19 are being reported in the literature. These most often include sudden anosmia, headache, encephalopathy, and stroke. The pathophysiological mechanisms underlying "Neuro-COVID" remain largely unknown, while the viral genome is very rarely detected in the cerebrospinal fluid. A study currently ongoing at the Cliniques universitaires Saint-Luc is aimed at investigating COVID-19 associated cerebrospinal fluid changes as well as immunohistochemical evidences of olfactory neuroepithelial cells direct viral infection and evidencing a direct infection of olfactory neuroepithelial cells.

Key Words

COVID-19, SARS-CoV-2, encephalitis, cerebrospinal fluid, olfactory neuroepithelium