Staphylococcal scaled skin syndrome (SSSS) is an exfoliating skin disease that predominantly affects newborns and young children. This infectious exanthema, characterized by superficial epidermis detachment, is due to Staphylococcus aureus infection excreting exfoliative toxins A and/or B. This case report illustrates the clinical signs of SSSS characterized by an erythrodermic and blistering skin rash with erythematous and oozing lesions in friction areas. The diagnosis of SSSS was clinically established. A positive evolution was observed under intravenous antibiotic treatment with flucloxacillin and clindamycin associated with movicol®, local care, and hydro-electric re-equilibration. We have addressed the physiopathology and differential diagnosis of SSSS, highlighting the relevance of early diagnosis.
Then, we have discussed guidelines about the treatment/management, and particularly the benefits of combining clindamycin and an osmotic laxative, infusion of fresh frozen plasma, or intravenous immunoglobulins in case of antibiotic resistance.
Staphylococcal scaled skin syndrome (SSSS), exfoliative skin disease, adolescent, bullous, exfoliative toxins, clindamycin