Synovial biopsy: an essential tool for guiding rheumatoid arthritis treatment?

L. Meric de Bellefon, M.S. Stoenoiu, Ch. Galant, A. Avramovska, S. Nieuwland Husson, A. Nzeusseu Toukap, B. Lauwerys, F.A. Houssiau, P. Durez Published in the journal : February 2016 Category : Rheumatology

Over the last years, the management of rheumatoid arthritis (RA) has been largely improved owing to the introduction of biologicals. These agents have been developed based on a better understanding of the disease pathophysiology. In the next years, the histopathological and molecular features of the synovial tissue will likely help clinicians better define RA treatment strategies.

Read more


O. Lebecque, V. Godding, P. Lebecque Published in the journal : February 2016 Category : Pneumologie pédiatrique

Your money or your life? - Kalydeco®: a milestone towards the “cure” of cystic fibrosis From February 1st 2016 on, Ivacaftor (KALYDECO™) will be reimbursed in Belgium for the treatment of cystic fibrosis (CF) in patients aged 6 years and older carrying at least one of nine well characterized gating (Class III) cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations, which account for approximately 3% of Belgian CF patients. In most of these patients, this very expensive oral drug (248,000 €/year) substantially improves lung function, lowers sweat chloride levels, and improves body weight by targeting the primary defect, thus representing a fundamental shift in the way the disease is managed. However, clinicians should be aware of the drug's potential for numerous drug interactions.

Read more

The child and adolescent psychiatry department: 2015 highlights

E. de Becker, N. Chatelle, P. Kinoo, E. Mousset, A. Wintgens Published in the journal : February 2016 Category : Psychiatrie infanto-juvénile

In 2015, the child and adolescent psychiatry department initiated measures aimed to comply with the guidelines that have been produced as part of the mental health care reform initiated by the federal and regional authorities (setting up of networks, of a mobile crisis team, etc.). At the Saint-Luc hospital, three interesting initiatives should be worth mentioning. The SOS-CHILDREN team has opened a space pertaining to the "repair" of the parent-child relationship, for the event of documented child abuse instances requiring the child’s placement. Besides, the KaPP team has proposed a therapeutic strategy designed to deal with parental refusal of medical treatment deemed necessary by healthcare professionals. Lastly, the CRA team has developed a tool for assisting both parents and child after the diagnosis of autism has been made by setting up a social skills training group.”

Read more


M. Luyckx, J. Squifflet, J.F. Baurain, D. Bourgonjon, A. Gerday, P. Laurent, C. Pirard, C. Watremez, F. Roelandt, C. Rousseau, M. Berlière, Ch. Wyns Published in the journal : February 2016 Category : Gynecology and Obstetrics

The gynecology-andrology department presents several major innovations developed in 2015. Advances have been achieved in the fields of both treatment strategies, as illustrated by the implementation of the sentinel node technique for pelvic cancers, and of quality of life during patient care, especially via using hypnosis while treating benign and malignant breast diseases or in reproductive medicine.

Read more

Novelties and innovations in physical medicine: What are the lessons learned from the year 2015?

S. Salazar Gajardo, T. Lejeune, S. Fizaine, I. de Biourge, G. Caty Published in the journal : February 2016 Category : Physical and Rehabilitation Medicine

In physical medicine and rehabilitation, the year 2015 was notably marked by the continued implementation of exercise medicine in Belgium, in addition to the publication of additional evidence and supplementary information regarding the usefulness of supervised exercise in the prevention and therapeutic management of chronic diseases. In addition, recent randomized controlled trials have been instrumental in supporting the need that physical exercise be integrated in the global management of cancer patients.

Read more

2015 innovations in orthopedic surgery and traumatology

N. Irda, D. Putineanu, K. Tribak, X. Libouton, O. Barbier, M. Van Cauter, J.-E. Dubuc, E. Thienpont, J.-C. Yombi, Th. Schubert, L. Kaminski, M. Mousny, P.-L. Docquier, X. Banse, Ch. Delloye, O. Cornu Published in the journal : February 2016 Category : Chirurgie orthopédique et traumatologie

Orthopedic surgery has been driven by technological advances for several years, thereby facilitating joint replacements while helping restore joint function and patient autonomy. New prostheses regularly emerge. They provide solutions to the problems posed by current joint replacements and render new joint replacements foreseeable, as is the case for the ankle and wrist.

Read more


M. Baeck, A. Herman, V. Dekeuleneer, A.-C. Deswysen, P.-D. Ghislain, B. Leroy, L. de Montjoye, I. Tromme Published in the journal : February 2016 Category : Dermatology

2015 was an important year in dermatology, especially in the therapeutic area. New treatments are available for chronic urticaria, psoriasis and angiofibromas of the face in the tubrous sclerosis complex context. In dermato-oncology, treatments of advanced cases of basal cell carcinomas and metastatic melanomas have significally improved. Finally, methylisothiazolinone remains a major allergen, responsible for contact allergy epidemic and for which it is urgent to establish a limitation of its use at European level.

Read more

Colorectal surgery in the robotic era

R. Bachmann, D. Léonard, N. Abbes Orabi, Ch. Remue, A. Kartheuser Published in the journal : February 2016 Category : Chirurgie colorectale

The year 2015 has been marked by the initiation of robotic-assisted colorectal surgery at the Cliniques universitaires Saint-Luc. Robotic surgery is a new surgical technology, which attempts to overcome the technical limitations of laparoscopic surgery. Contrary to the rectilinear and rigid instruments used in classical laparoscopy, the robot’s arms and instruments allow for intuitive movements that perfectly mimic those of the surgeon’s wrist and hand. Along with the 3D magnified vision of the operating field and filtering of physiological tremor, these features in addition to others are key to the precision and safety of minimally invasive surgery.

Read more

A rare cause of painful peripheral edema

C. Jonard, J.-B. Nicolas Published in the journal : September 2015 Category : General Internal Medicine

Many conditions may cause painful edema of one or more extremities. Eosinophilic fasciitis (EF), also called Shulman syndrome, is an uncommon one, evolving into sclerodermoid cutaneous infiltration, associated with peripheral blood eosinophilia. EF is a fibrotic disease of muscle fascia and skin, whose etiology remains unclear. Several pathophysiological mechanisms have nevertheless been proposed, the major component being an imbalance between extracellular matrix production and degradation. Visceral involvement is uncommon. EF may be associated with blood disorders, which determine its prognosis. The diagnosis is confirmed by elliptical full-thickness incisional biopsy of skin and subcutaneous tissues down to the muscle surface. EF is most likely underdiagnosed due to its rarity and its similarities with other conditions, such as systemic sclerosis. The typical first-line treatment is systemic corticosteroid therapy tapered over several months. Cortico-resistant and severe-onset forms require adding another immunomodulatory agent. In this case report, we describe a typical presentation of EF, highlighting the diagnostic difficulties posed by this uncommon pathology. Based on a literature review, we also recall its underlying pathophysiological mechanisms, along with the diagnostic and therapeutic steps.


Read more

Approvement of a new combination of atorvastatin and ezetimibe What changes are to be expected "From A to Z"

O.S. Descamps Published in the journal : January 2016 Category : Actualité thérapeutique

ATOZET ® contains two active agents, atorvastatin and ezetimibe, which inhibit the pathways pertaining to hepatic synthesis and intestinal absorption of cholesterol, thereby reducing the LDL levels by 50 to 65%. Each active ingredient has proven its effectiveness to significantly reduce the incidence of cardiovascular disease. From a practical point of view, the reimbursement conditions (INAMI/ RIZIV) for this combination pack have been rightly adjusted to the latest European and Belgian recommendations, allowing patients at very high risk to be optimally treated. The combination 'two in one' is also likely to facilitate therapeutic adherence. ATOZET ® is particularly indicated in secondary prevention, in primary prevention, and in patients with a very high SCORE (≥10%), patients with diabetes, or those with familial hypercholesterolemia whose LDL cholesterol levels remain inadequately controlled by statin monotherapy alone.

Read more