Treatment adherence in cardiovascular prevention : the lipidologist's point of view

Olivier S. Descamps Published in the journal : September 2018 Category : GRAPA

The "sneaky" aspect of the risk associated with high blood cholesterol given its asymptomatic nature before complications arise makes hypolipidemic treatment often problematic for our patients. This is especially so because the side effects that can occur such as myalgia and the polemics diffused through the media by some critics cause worry and doubts in our patients. In this article, we will discuss three of the most frequently encountered problems and how to address them.

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Guselkumab, an effective interleukin-23 inhibitor in the treatment of psoriasis

Caroline Colmant, Pierre-Dominique Ghislain (1) Published in the journal : September 2018 Category : Actualité thérapeutique

Guselkumab is a selective interleukin-23 inhibitor that has been marketed and reimbursed since a few months in Belgium. We conducted a literature review in order to assess the efficacy and safety of guselkumab.

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News from the GRAPA (task force for the prevention of atherothrombosis) 9th GRAPA symposium (3rd March 2018)

Alexandre Persu Published in the journal : September 2018 Category : GRAPA

The news from the GRAPA provide a summary of the presentations made at the 9th GRAPA symposium, with a focus on treatment adherence in the prevention of cardiovascular diseases, mainly in the areas of lipidology, diabetology, and rhythmology. The presentations also addressed related topics, such as therapeutic inertia, therapeutic education, empowerment, and the impact of treatment-related adverse events and media controversies on the initiation and continuation of cardiovascular medications. Finally, arguments for the control of cardiovascular risk factors in the prevention of atrial fibrillation, based on recent medical literature, are also presented. 

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Treatment of hemophilia A: Which role for plasmaderived factor VIII in 2018?

Cédric Hermans Published in the journal : September 2018 Category : Actualité thérapeutique

After thousands of hemophilic patients were infected with HIV and HCV, and thanks to major advances in biotechnology, recombinant factor VIII has emerged as a first-line or reference treatment for most factor VIII-deficient patients (hemophilia A). The development of neutralizing antibodies (inhibitors) is currently the most severe and feared complication in hemophilia A replacement therapy. The respective immunogenicity of plasma and recombinant factor VIII concentrates has been debated for many years, with multiple studies providing contradictory results.

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XULTOPHY®, A COMBINATION OF BASAL INSULIN AND LIRAGLUTIDE: ROLE IN THE TREATMENT OF TYPE 2 DIABETES

Martin Buysschaert Published in the journal : September 2018 Category : Diabétologie

Xultophy® is a new combination product consisting of basal insulin (degludec) and a GLP-1 agonist (liraglutide). In this article, we analyzed recent literature in order to find out its potential advantages in general and compared to basal insulin in particular, as well as to clarify its role in the therapeutic management of insulinrequiring type 2 diabetes. 

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Comparison of tacrolimus plus induction via intraoperative single high-dose of rabbit anti-T-lymphocyte globulins versus tacrolimus monotherapy in adult liver transplantation: 1-year results of an investigator-driven randomized controlled trial

Kevin Ackenine(1), Samuele Iesari1, (2), Maxime Foguenne(1), Chantal De Reyck(1), Eliano Bonaccorsi Riani(1), Olga Ciccarelli(1), Laurent Coubeau(1), Quirino Lai(3), Mina Komuta(4), Pierre Gianello(5), Jan Lerut(1) Published in the journal : July 2018 Category : Mémoires de Recherche Clinique

The efficacy of anti-lymphocyte serum (ALS) induction remains inconclusive in liver transplantation (LT) due to poorly designed trials.

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Acute liver failure in children: experience of a paediatric intensive care unit

Valentine Hermans(1), Thierry Detaille(1), Astrid Haenecour(1), Emilien Derycke(1), Laurent Houtekie(1), Raymond Reding(2), Stéphan Clément de Cléty(1) Published in the journal : July 2018 Category : Mémoires de Recherche Clinique

Pediatric acute liver failure (PALF) is a rare yet severe condition characterized by rapidly progressing hepatic dysfunction and multisystem organ failure (MOF) syndrome in previously healthy children. It poses several clinical challenges to physicians, one of them being the identification of the children who won’t recover without liver transplantation (LT).

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Prognostic factors of acute mesenteric ischemia in the intensive care unit

Martin Caluwaerts(1), Diego Castanares-Zapatero(1), Pierre-François Laterre(1), Philippe Hantson(1) Published in the journal : July 2018 Category : Mémoires de Recherche Clinique

Acute mesenteric ischemia (AMI) is a frequent cause of acute abdomen in the elderly, which is commonly encountered in the intensive care unit (ICU). AMI has a high mortality rate of between 60 and 80%, as well as a high morbidity rate among survivors. One of the reasons for this poor prognosis is the lack of accurate diagnostic tools for the clinician, with a delayed diagnosis as the main consequence. The characteristics of AMI diagnosed in the ICU often differ from those found in the general population, which results in a real diagnostic challenge. In the ICU, the interpretation of clinical, biological, and radiological signs of AMI proves more difficult. Furthermore, the poor prognosis is also accounted for by the numerous comorbidities of intensive care patients.

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Impact of intraoperative 3D fluoroscopy-based neuronavigation during percutaneous pedicle screw fixation in the degenerative lumbar spine

Julien Pierrard, Christian Raftopoulos, Edward Fomekong Published in the journal : July 2018 Category : Mémoires de Recherche Clinique

Given the aging population and increasing prevalence of degenerative diseases of the spine, neurosurgeons need to perform more lumbar fusions with pedicle screw fixations. As these interventions are currently carried out percutaneously, surgeons are dependent on intraoperative imaging to replace the anatomical landmarks found in open procedures. In our institution, we recently acquired a neuronavigation system based on intraoperative 3D fluoroscopy.

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Extracerebral vascular phenotype in autosomal dominant polycystic kidney disease

Thibault Wallez, Nathalie Demoulin, Yves Pirson Published in the journal : July 2018 Category : Mémoires de Recherche Clinique

Autosomal dominant polycystic kidney disease (ADPKD), caused by PKD1 or PKD2 mutations, is the most common inherited kidney disease. Intracranial aneurysms (ICA) and mitral valve prolapses are well-known vascular complications in ADPKD patients. Other reported vascular manifestations include thoracic aortic aneurysms and dissections (TAAD) and cardiomyopathies (CMP).

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