Martin Buysschaert, Vanessa Preumont (1)Published in the journal : January 2019Category : Diabétologie
Suliqua® is a new fixed-ratio combination product of the basal insulin glargine 100U/mL and the GLP-1 receptor agonist lixisenatide. This article sought to analyze the recent literature to better identify the product’s potential advantages in general and more particularly, in comparison to basal insulin, and to clarify its precise place in the treatment algorithm for Type 2 diabetes in Belgium.
This paper aimed to review the clinical data on dapagliflozin (Forxiga®) treatment in the light of the recent DECLARE-TIMI 58 trial results. This study involving Type 2 diabetic patients, either with or without prior macroangiopathy, has demonstrated cardiovascular benefits in terms of the primary efficacy outcome, namely a composite of cardiovascular death and hospitalization for heart failure. Moreover, the study has revealed a lower risk for renal disease progression.
Pamela El Nemnom (1), Marie Baeck (1), Claire Dachelet (2), Liliane Marot (1)Published in the journal : December 2018Category : Dermatology
We have herein reported on the “PEAU’se dermatologique” meeting conducted at the Cliniques universitaires Saint- Luc on November 13, 2017, while being focused on bullous skin disease. After a brief reminder of the clinical lesions for each condition, the anatomopathological characteristics were specified, with the latest updates about their treatment provided. The newest update concerned rituximab that will now be reimbursed in the context of complicated bullous skin disease.
While acromio-clavicular dislocations are common lesions, the association with sterno-clavicular joint dislocation proves to be very rare, with less than fifty cases reported worldwide.
Laurent Truffaut(1), Caroline Vincent(1), Yves Coyette(2), Pierre Hanotier(2)Published in the journal : December 2018Category : Infectiologie
We have herein reported on the case of a 97-year-old patient suffering from hypoxemic pneumonia caused by Mycoplasma pneumoniae, complicated by severe rhabdomyolysis. The diagnosis was based on the clinical picture associated with an equivocal serology, after excluding other obvious rhabdomyolysis-based etiologies. The clinical and biological progression proved to be rapidly favorable following targeted antibiotic therapy. After clarifying the unusual rhabdomyolysis etiology within a Geriatric Unit, we have further insisted on both the search and treatment of atypical bacteria when the clinical and radiological presentations point towards these conditions.
The differential diagnosis of nasopharyngeal masses is vast and mainly comprises three categories of lesions: benign masses corresponding to benign tumors and inflammatory lesions, malignant tumors, and congenital lesions. The age of the patient, clinical context, symptoms associated with the mass, as well as iconographic data are essential to orientate professionals towards the various possible etiologies. In a context of hypothalamic-pituitary axis malformation, and with reference to the embryological origins of the pituitary gland, the hypothesis of extracranial ectopic pituitary tissue is, although rare, an etiology that must be evoked when confronted to a nasopharyngeal mass. However, biopsy with an anatomopathological examination proved to be the only technique able to confirm the lesion’s histological origin.
Morgane Slaedts(1), MD, Alain Poncelet(2), PhD, Stéphane Moniotte(1), PhDPublished in the journal : December 2018Category : Cardiovasculaire
The anomalous origin of the right coronary artery from the pulmonary artery (ARCAPA) is a rare congenital heart disease, with an incidence of 0.002%. Often asymptomatic upon childhood, the diagnosis is easily missed, with the anomaly often diagnosed incidentally. Nevertheless, ARCAPA may lead to myocardial ischemia or sudden cardiac death, even in early childhood.
Michèle J. Yerna (1), Cristian R. Tarta (1), Juline A. Verjans (2), Renaud A. Verjans (2), Amir S. Aouachria (3)Published in the journal : December 2018Category : Cardiovasculaire
The Lazarus phenomenon is characterized by spontaneous recovery of circulation after cessation of cardiopulmonary resuscitation. The pathophysiological mechanism is still unknown. We have reported the case of a 61-year-old man who collapsed owing to cardiac arrest after anaphylactic shock in relation to hymenoptera bites. Advanced life support was initiated within 10 minutes, and an alternation of shockable and non-shockable rhythms was observed over 60 minutes. Following intravenous administration of 14mg epinephrine and six external electric shocks, treatment was stopped. Monitoring system was maintained, and 5 minutes later, a spontaneous return of electrical activity with palpable pulse was noted. Despite an aggressive treatment, the patient died 12 hours later from refractory shock.
Emilie Evrard (1), Dan Gusu (2), Pierre Hausman (3), Denis Glorieux (4)Published in the journal : December 2018Category : Cardiovasculaire
The atrioesophageal fistula (AEF) is a rare complication of the atrial fibrillation (AF) ablation procedure. This complication is mostly fatal, with a mortality rate exceeding 80% (1), while its incidence does not exceed 0.3% (1). It is the second cause of death after tamponade following this procedure (2). The AEF results from the proximity between the esophagus and left atrium (3), as well as fromthermal esophageal mucosal lesions (4). We have here reported the case of a 65-year-old man who developed neurologic and septic symptoms 31 days after a second AF ablation. Upon admission, a cerebral scanner revealed a small ischemic lesion in the right temporal lobe. Initially hospitalized in a stroke unit, the patient was then transferred to an ICU because of his rapid neurologic deterioration. Upon the intubation maneuver, massive hemorrhaging from an upper digestive site occurred, with patient reanimation required. Confronted with an unknown diagnosis, a gastric endoscopy was performed, revealing two sluices on the anterior esophagus surface, opposite the left atrium. Thoracic CT scan corroborated the AEF diagnosis with an air bubble observed in the mediastinum, between esophagus and left atrium. Nevertheless, the patient died owing to massive cerebral air embolism.
Pauline Van Gyseghem, Etienne Sokal (1)Published in the journal : December 2018Category : Pediatrics
With about 11 million children suffering from chronic hepatitis C infection worldwide, hepatitis C remains a major concern in pediatrics. In children, the main source of transmission is vertical, from the mother to the child around birth. Overall, 80% of infected children will develop a chronic infection, with about 1-2% evolving into hepatic cirrhosis. Pediatric treatments aim to eradicate the virus in order to reduce the transmission risk and prevent tissue damage in the long-term. Classical treatments based on pegylated interferon and ribavirin allow sustained virologic response to be achieved in about 45 to 95% of cases (1). In adults, new direct-acting antiviral (DAA) regimens have been approved in recent years and are now being used in the first-line setting. The first successful study that tested their efficacy in a pediatric population reported a sustained virological response in 97 to 100% of cases (2). If this rate is confirmed in other ongoing studies, disease eradication in the pediatric population should be feasible, enabling us to eradicate the virus reservoir, a latent source of new contaminations and chronic liver diseases.