Glucocorticoid-induced muscle atrophy: clinical presentation, physiopathological mechanisms, and therapeutic implications

Pauline Montigny (1), Jean-Paul Thissen (2) , Bernard Lauwerys (3), Frédéric Houssiau (3) Published in the journal : September 2019 Category : Rheumatology

Glucocorticoids (GC) are used in all medical areas because of their anti-inflammatory and immunosuppressive effects. Their undesirable effects are, however, much feared, in particular cortisone-induced myopathy (CD). This condition is characterized by insidious muscle atrophy, exhibiting an important prognostic role. CD is related to the GC-induced imbalance between muscle protein synthesis and degradation, promoting their degradation yet inhibiting their synthesis. We have herein undertaken a review focused on CD’s main pathophysiological mechanisms, along with a discussion on potential targets, such as myostatin, activin receptor Type IIB, TRAF6, and REDD1. To end with, practical recommendations for the fight against CD have been developed, including resistance exercises.

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Diagnostic and therapeutic innovations in rheumatology in 2018

Bernard R. Lauwerys Published in the journal : February 2019 Category : Rheumatology

Novel therapeutic developments are increasing in the field of rheumatology, particularly with respect to inflammatory and systemic rheumatisms.

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Spondyloarthritis: New insights in the pathophysiology and therapeutics perspectives!

A. Nzeusseu Toukap Published in the journal : February 2016 Category : Rheumatology

Spondyloarthritis (Spa) is a chronic immune-mediated inflammatory disease characterized by skeletal involvement (axial, an peripheral or both), at times associated with extra-articular manifestations (skin, gut, or eye). This heterogenic rheumatic disease may cause structural and functional impairments, in addition to a decrease in patients' quality of life. A better understanding of the disease's pathophysiology has led to new encouraging therapeutics strategies for managing this disease.

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Synovial biopsy: an essential tool for guiding rheumatoid arthritis treatment?

L. Meric de Bellefon, M.S. Stoenoiu, Ch. Galant, A. Avramovska, S. Nieuwland Husson, A. Nzeusseu Toukap, B. Lauwerys, F.A. Houssiau, P. Durez Published in the journal : February 2016 Category : Rheumatology

Over the last years, the management of rheumatoid arthritis (RA) has been largely improved owing to the introduction of biologicals. These agents have been developed based on a better understanding of the disease pathophysiology. In the next years, the histopathological and molecular features of the synovial tissue will likely help clinicians better define RA treatment strategies.

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