Hematology & dermatology

Déborah Debois (1), Liliane Marot (1), Eric Van Den Neste (2), Alessandra Camboni (3), Isabelle Tromme (1) Published in the journal : January 2019 Category : Dermatology

Summary :

We here briefly summarize the “PEAUse dermatologique” meeting organized in February 2018 by the Department of Dermatology of the Saint-Luc University Clinics and dedicated to cutaneous lymphomas. Professor E. Van Den Neste presented the most frequent cutaneous lymphomas, their treatments, as well as several clinical cases from the Department of Hematology. Professor A. Camboni focused on the histological aspects.

Key Words

Cutaneous lymphoma, Sézary syndrome, mycosis fungoides, CD30+ lymphoprolifetative disorders

What is already known about the topic?

Primary cutaneous T-cell lymphomas are the most common form of extranodal non-Hodgkin T-cell lymphoma after digestive lymphomas. They form a very heterogeneous group in terms of clinical manifestations, evolution, histological characteristics, molecular profile, and prognosis. Epidermotropic lymphomas (mycosis fungoides and Sézary syndrome) account for 60% of all primary cutaneous T-cell lymphomas and differ from each other in evolution and prognosis. Other rare forms exist, such as CD30+ lymphoproliferative disorders, CD4+ small/medium-sized pleomorphic lymphomas, as well as hypodermic lymphoma. More rarely, skin involvement may be secondary to systemic lymphoma infiltration.

What does this article bring up for us?

This article recalls the clinical aspects allowing the diagnosis of the different types of cutaneous lymphomas. It also reviews the treatments of cutaneous epidermotropic lymphomas (mycosis fungoides and Sézary syndrome). Finally, it provides histological tips to differentiate between the different lymphoma types when the clinical diagnosis proves complicated.