Rare and serious complications related to granulomatosis with polyangiitis

Published in the journal : April 2018 Category : Internal Medicine

Summary :

Granulomatosis with polyangiitis is a rare systemic vasculitis with significant morbidity and mortality. The diagnosis is based on the association of clinical signs, such as involvement of upper and lower respiratory tract, as well as of the kidney, along with the presence of specific antibodies (ANCA anti-PR3), and confirmation of histopathological biopsy specimen. Although the current treatment of the disease has resulted in significantly reduced mortality, morbidity remains very high, which is linked to both the disease itself and the undesirable effects of immunosuppressive therapy.

Key Words

Granulomatosis with polyangiitis, complication, spleen infarction, atrioventricular block

What is already known about the topic?

Granulomatosis with polyangiitis proves to be a serious disease with potential multiple complications that require a complex treatment initiation.

What does this article bring up for us?

Despite early treatment and according to the recommendations, patients may develop disease manifestations of varying severity grades.