Clinical and biological presentation of primary hyperparathyroidism depending on vitamin D status

M. Yazidi, M. Chihaoui, F. Chaker, M. Feki, H. Slimane Published in the journal : December 2016 Category : Endocrinologie et diabétologie

Summary :

Primary hyperparathyroidism (PHPT) and vitamin D deficiency are two common diseases. Their combination seems also to be common and might influence the clinical and biological expression of PHPT. Forty two patients with PHPT in whom vitamin D (25OHD) was measured at diagnosis were studied retrospectively. Vitamin D deficiency (plasma 25OHD<10ng/ml) was observed in 40,5% of PHPT patients. Osteopenia and osteoporosis were more frequent (p=0,01) and PTH level was higher (567,9±697,0 µg/l vs 259,8±198,8 µg/l p=0.04) in patients with vitamin D deficiency. Low plasma 25OHD levels may contribute to the severity of PHPT. Measurement of 25OHD should be routinely performed in PHPT patients to better assess the severity of the disease and to consider possibly vitamin supplementation.

What is already known about the topic?

Primary hyperparathyroidism (HPTP) and vitamin D deficiency are common disorders, and their coexistence also appears to be common, which may exacerbate the clinical and biological manifestations of HPTP.

What does this article bring up for us?

This article demonstrates, through the study of the vitamin D status of 42 patients with primary hyperparathyroidism (HPTP), that in the presence of vitamin D deficiency, the clinico-biological feature of HPTP is more severe. It therefore incites the clinician to systematically assay vitamin D in any patient with HPTP.

Key Words

Primary hyperparathyroidism, vitamin D, parathyroid hormone, osteoporosis