Diagnosis of primary bilateral macronodular adrenal hyperplasia and evaluation of aberrant receptors. A case report.

Corinne Jonas, Christophe Hommel, Julian Donckier Published in the journal : May 2015 Category : Endocrinology

Summary :

Primary bilateral macronodular adrenal hyperplasia is a rare condition that may be responsible for Cushing's syndrome. We report herein the case of a patient presenting with bilateral adrenal incidentalomas causing subclinical hypercorticism. Aberrant receptors were searched for, suggesting the presence of vasopressin and serotonin receptors. As there is currently no specific treatment available to block these receptors, it has been proposed to follow-up the patient who did not present any hypercorticism-related complication.

What is already known about the topic?

Bilateral macronodular adrenal hyperplasia is a rare cause of Cushing's syndrome. In this case, steroidogenesis is regulated by the presence of one or more aberrant receptors. Cushing 's syndrome, even if subclinical, is burdened with increased morbidity and mortality. Treatment depends on the hypercortisolism severity.

What does this article bring up for us?

In this article, we have reviewed the management and treatment of bilateral macronodular adrenal hyperplasia.

Key Words 
Primary bilateral macronodular adrenal hyperplasia, aberrant receptors, Cushing’s syndrome