Introduction
While granuloma annulare is a benign disease, little is known about its pathophysiology, etiology, and comorbidities. Furthermore, its treatment remains poorly standardized. In this case report, we have reviewed and discussed the literature dealing with granuloma annulare, with a special focus on the advisable evaluations and therapies.
Clinical observation
A 58-year-old man who had already been followed up for generalized granuloma annulare over 2 years sought a second medical opinion. He had previously been treated with topical corticoids, phototherapy, bath-PUVA therapy, hydroxychloroquine, dapsone, and methotrexate, without satisfactory results. Therapeutic abstention was then proposed to the patient.
Conclusion
Only dyslipidemia is significantly associated to granuloma annulare. The treatment of generalized granuloma annulare is based on low level evidence. A full work-up is not always necessary. Therapeutic abstention may be an option to consider, either after multiple therapeutic failures, or if the patient does not wish to be treated or has previously experienced treatment-related adverse effects.
What is already known about the topic?
Granuloma annulare is a benign disease whose pathophysiology, etiology, and comorbidities are not well known, while its treatment is poorly standardized.
What does this article bring up for us?
In this case report, we reviewed and discussed the literature concerning granuloma annulare, with a special focus on the advisable evaluations and therapies. Key words Granuloma annulare, work-up, therapy
Key words
Granuloma annulare, work-up, therapy