Spondyloarthritis: New insights in the pathophysiology and therapeutics perspectives!

A. Nzeusseu Toukap Published in the journal : February 2016 Category : Rheumatology

Summary :

• Spondyloarthritis (Spa) is a chronic immune-mediated inflammatory disease characterized by skeletal involvement (axial, an peripheral or both), at times associated with extra-articular manifestations (skin, gut, or eye)

• This heterogenic rheumatic disease may cause structural and functional impairments, in addition to a decrease in patients' quality of life.

• A better understanding of the disease's pathophysiology has led to new encouraging therapeutics strategies for managing this disease.

Key words

Spondyloarthritis, pathophysiology, enthesitis, therapeutic, TNFa blockade agents, IL-23R, IL-17