The beginning of 2020 was marked by the spread of SARS-CoV-2 virus, a new virus from the beta-coronavirus family, from Hubei, China. This virus is responsible for a global pandemia of pneumonia with acute respiratory distress syndrome. Although the infection appears to be less acute in the pediatric population, neonates tend to be more frequently affected. Several cases of neonatal SARS-CoV-2 infections have been reported to date, including one in an extremely premature neonate. Nevertheless, the clinical picture seems to be less critical and neonatal mortality associated with COVID-19 has not been reported to date. The transmission mode from mother to infant has not been clearly demonstrated so far. Breastfeeding is allowed in most countries. The aim of this article is to summarize the epidemiological context and current knowledge on COVID-19 in infants and neonates.